Research Progress on DNA Methylation in Domestic Animal Reproduction
LUO Rui-Rui, WANG Cai-Lian, LANG Xia*
Key Laboratory of Bovine and Ovine Germplasm and Straw Transfer into Feedstuff in Gansu Province, Animal Husbandry, Pasture and Green Agriculture Institute, Gansu Academy of Agricultural Sciences, Lanzhou 730070, China
Abstract：DNA methylation is the process of the covalent binding of a methyl group the fifth carbon position of the cytosine of CpG dinucleotide of the genome under the action of DNA methyltransferase. As one of the important epigenetic modification mechanisms, it is a hot topic in the field of life science. With the rapid development of sequencing technology, DNA methylation detection technology has also made significant progress. In terms of animal reproduction, changes in the degree of DNA methylation may affect the expression of genes related to reproductive traits, thus changing the reproductive performance of animals. In this paper, a brief review is made on the overview of DNA methylation, the detection methods of DNA methylation and the research on animal reproduction, and the apparent genetic mechanism of DNA methylation is explored. This review provides a theoretical basis for molecular breeding to give full play to the fertility of domestic animals and select high-quality new varieties or strains.
雒瑞瑞, 王彩莲, 郎侠. DNA甲基化在家畜繁殖中的研究进展[J]. 农业生物技术学报, 2023, 31(10): 2190-2199.
LUO Rui-Rui, WANG Cai-Lian, LANG Xia. Research Progress on DNA Methylation in Domestic Animal Reproduction. 农业生物技术学报, 2023, 31(10): 2190-2199.
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