Abstract：In this paper, intestinal microbiota of ICR mice fed with Cry1C protein in acute oral toxicity test were analyzed, furthermore, edible safety of insect-resistant protein was evaluated deeply. DGGE maps by UPGAMA cluster analysis indicate that the intestinal flora in the mice of this study show significant difference; the mouse in the control group have unique and stable intestinal flora in this test period; the intestinal flora of the mouse in the test group have significant changes before and after gavage, however, the diversity in test group decreases gradually, and restore the structure of pre-administered after the peak. Therefore, Cry1C protein is safe for mice from the point of intestinal microbiota.
