Abstract:Abstract: The genetic diversity of wild and cultured Exopalaemon modestus in Taihu Lake was analyzed by random amplified polymorphic DNA (RAPD) technique . 23 random primers were selected from 60 random primers ,which could amplify 105 fragments in total with the fragment lenth varing from 200 to 2000 bp. The resuts using PopGen1.32 showed the proportion of polymorphic loci of wild and cultured Exopalaemon modestus was 50.47% and 43.33%,respectively. The intra-population genetic similarity of wild and cultured population was 0.8635 and 0.8795 respectively ,while inter-population genetic distance between the two populations was 0.0361. The mean Shannon index H0 was 0.2830 in wild population ,which was slightly higher than the value 0.272 in cultured population.