Research Progress on the Regulation of Host MEK/ERK SignalingPathway by Viral Infection
ZENG Jian-Yu1,2, GAO Peng1,2, ZHOU Lei1,2, GE Xin-Na1,2, ZHOU Qiong-Qiong1,2, HAN Jun1,2, GUO Xin1,2, ZHANG Yong-Ning1,2*, YANG Han-Chun1,2
1 National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; 2 Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
Abstract：The mitogen-activated protein kinase kinase/extracellular regulated protein kinases (MEK/ERK) signaling pathway is a crucial intracellular signal transduction system that plays a pivotal role in regulating fundamental cellular processes including cell proliferation, differentiation, and apoptosis and so on. Recent studies have demonstrated that this signaling pathway also serves important regulatory functions in virus-host interactions. This paper comprehensively reviews the research progress on how viruses modulate biological processes such as apoptosis, autophagy, and the production and secretion of inflammatory factors through the MEK/ERK signaling pathway. Furthermore, it also provides an in-depth analysis of the current research status and potential therapeutic applications of MEK/ERK signaling pathway inhibitors as promising antiviral strategies. This review offers significant theoretical foundations and new research directions for the development of antiviral drugs.
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