Abstract：The inappropriate utilization of antibiotics has precipitated a multitude of concerns, prominently featuring drug residues and the proliferation of drug-resistant bacteria. Drug residues, by way of the food chain, can inflict deleterious effects on human health and instigate ecological environmental contamination. Concurrently, drug-resistant bacteria present formidable challenges in the treatment of infectious diseases, engender a substantial escalation in medical expenditures, and, in severe cases, imperil human lives. Antimicrobial peptides (AMPs), with their multiple biological functions and unique mechanisms of action, have emerged as promising alternatives to antibiotics. Furthermore, their low toxicity and reduced likelihood of resistance development have driven research beyond theoretical studies to practical applications in production systems. This review summarizes the mechanisms of action of AMPs and their research and applications in clinical practice, the food industry, and agricultural production. The review provides a theoretical foundation for developing novel anti-infection strategies, ensuring food safety, and promoting sustainable agriculture. This work holds critical value for addressing global antimicrobial resistance challenges and achieving sustainable development goals.
高楠, 李逸涵, 孙佳琦, 毕重朋, 单安山, 王家俊. 抗菌肽应用研究进展[J]. 农业生物技术学报, 2025, 33(6): 1382-1397.
GAO Nan, LI Yi-Han, SUN Jia-Qi, BI Chong-Peng, SHAN An-Shan, WANG Jia-Jun. Research Progress on the Application of Antimicrobial Peptides. 农业生物技术学报, 2025, 33(6): 1382-1397.
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