Abstract:Ochratoxin A(OTA) is a mycotoxin produced by several kinds of fungi growing on food source materials. The main target of OTA is the kidney and liver. However, its plant toxicity is rarely reported. In this paper, we studied the plant toxicity by OTA in Arabidopsis thaliana through the phenomenon and expression of protein during the cell necrosis. The results showed that plant growth was obviously inhibited by OTA, especially the roots and leaves; Trypan blue staining, Evans blue staining and DNA ladder showed that OTA could lead Arabidopsis thaliana cell necrosis, cell membrane integrity damage and DNA crack; Two-dimensional gel electrophoresis maps illustrated that OTA could induce different protein expression in A. thaliana. Some proteins were up regulated, and some others proteins were down regulated, even disappeared. The research indicates the plant toxicity of OTA.