Abstract:Paraoxonase is a HDL-associated esterase, and is proposed to play a key role in lipid metabolism and the onset of cardiovascular diseases. The objectives of the present study were to determine associations between these polymorphisms of PON1 gene and growth and carcass traits. For this purpose, genotyping was performed on males of 18 Angus, 23 Jinnan cattle, 20 Limousin, 28 Luxi cattle, 26 Qinchuan cattle, 29 Simmental, 29 Charolais. In the association studies traits of interest were analyzed using the RFLP-PCR and GLM procedure of SAS 9.1 and least square means of the genotypes were compared by the Tukey’ s test. Association of PON1/ EcoRⅤ genotypes with body weight, average daily gain, rib eye area and tenderness were significant (p < 0.05), and AG genotype was significant difference with others in average daily gain and tenderness (p < 0.05), with AA genotype may have higher rib eye area (p < 0.05). The association analysis of the PON1/ AluⅠ polymorphism showed significant associations between genotypes and growth: body weight and carcass traits net meat weight and tenderness (p < 0.05). AA genotype was considered more favorable than others in all growth and production traits. There were significant differences among breeds for all associated interests traits and difference between beef breeds and native breeds are obviously in all aspects. And these results may be useful for the breeding selection.