Abstract：Based on the cyclophosphamide (CP) induced immunosuppressed mice model, we investigated the effect of the enriched-selenium polysaccharide produced by Z0206 on the immunoloregulation in mice. The mice were divided into 4 groups, control groupⅠ, CP group Ⅱ, enriched-selenium polysaccharide group Ⅲ and prevetion of enriched-selenium polysaccharide group Ⅳ. They were given different doseages of normal saline or the enriched-selenium polysaccharide Z0206 by gavage respectively. Compared to the control group, immunosuppression appeared in the CP group. Results showed that compared with the CP group, the enriched-selenium polysacchride Z0206 could remission the immunosuppression, enhanced the spleen and thymus index(p<0.05), regulated T cell subsets(p>0.05), enhanced the NK cell activities(p<0.05), raised the plapue forming cell assay and hemolysin level in mice (p<0.05). However, compared with the control group, the spleen and thymus index, T cell subsets, NK activity, and humoral immunity increased significantly(p<0.05). Conclusion: the enriched-selenium have obvious improvement and arrest of immunosuppression induced by CP in mice.
