Research Progress on Functionalized Ferritin Nanoparticle Vaccine
ZHANG Rong1,2,3, WEI Yan-Ming1,*, RU Yi3
1 College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China; 2 China Agricultural Vet. Bio. Science and Technology Co., Ltd., Lanzhou 730046, China; 3 Gansu Province Research Center for Basic Disciplines of Pathogen Biology/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences/College of Veterinary Medicine, Lanzhou University/State Key Laboratory for Animal Disease Control and Prevention, Lanzhou 730046, China
Abstract：Among the multitude of nanocarriers, protein nanoparticles are hot topic in vaccine nanobiotechnology due to their biocompatibility, and flexibility of design. Compared with isolated protein subunits, protein nanoparticle vaccines are more readily taken up by antigen-presenting dendritic cells. Ferritin is a ubiquitous iron storage and detoxification protein that protects cells from iron-induced oxidative damage. Ferritin have remarkable chemical and thermal stability, reversible assembly and disassembly processes, and ability for engineering to display antigens. Ferritin is not only a useful nanoreactor and nanocarrier, but also an effective platform for vaccine development platform. This review summarized structure-function properties, self-assembly, novel bioengineering strategies, production and purification of ferritin nanoparticles, and functionalization of ferritin. Application progress and foreground to the field of vaccine development of ferritin were also discussed. This review provides theoretical support for nanobiotechnology in vaccine development.
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