Abstract：Programmed cell death (PCD) is a line of the innate immune defense system, and plays an important role in the growth development and immune regulation of the organism. As a new PCD pathway, PANoptosis is regulated by the multi-protein complex PANoptosome, which can simultaneously regulate the three key modes of programmed cell death including pyroptosis, apoptosis and necrosis, thereby defending against invasion of various pathogens. Consequently, studying the mechanism of PANoptosis is of great significance for deepening the understanding of cell death patterns, suggesting the occurrence of inflammation and diseases. In this paper, the concept, mechanism of action, molecular composition and assembly method of PANoptosis were reviewed, then a view was proposed that the formation of PANoptosome was a sign of PANoptosis in cells. This review provides new ideas for the treatment of inflammatory diseases.
王怡茹, 王远, 曹玲霞, 杨洁, 王书敏. 细胞泛凋亡的分子组成及作用机制[J]. 农业生物技术学报, 2024, 32(4): 882-891.
WANG Yi-Ru, WANG Yuan, CAO Ling-Xia, YANG Jie, WANG Shu-Min. Molecular Composition and Mechanism of Action of PANoptosis. 农业生物技术学报, 2024, 32(4): 882-891.
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