Advances in m6A Methylation Regulating Mammalian Gamete Maturation and Embryo Development
ZHANG Meng-Ya, YAN Ye-Lian, WANG Xin, LIU Qiu-Chen, ZHANG Yun-Hai*, CAO Zu-Bing*
Anhui Provincial Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Breeding, College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
Abstract：Gamete maturation and embryo development are key factors that determine mammalian reproduction. Gamete maturation and embryo development are regulated by a variety of epigenetic information. N6- methyladenine (m6A) specifically refers to the endogenous methylation modification on the sixth N atom of RNA adenine, which is the most abundant internal modification in mammalian mRNA and affects many aspects of RNA metabolism. m6A plays an important role in mammalian gamete maturation and embryo development. Abnormal modification of m6A impairs gametogenesis, sex hormone synthesis, fertility and early embryo development. This review focuses on the studies of m6A modification related enzymes and their regulation role in mammalian gamete maturation and early embryo development, which provides references for the further exploring the mechanism of m6A regulation of mammalian gamete maturation and embryo development.
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