Abstract：The study was to investigate the lipid-lowering and anti-obesity function and mechanism of Malus xiaojinensis polyphenols (MXP). Hyperlipemia mice (Mus musculus) model was established by feeding high-fat diet and MXP gavage administration (50 and 100 mg/kg) for 7 weeks. The levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) in serum, the TG and TC in liver, the liver and spleen index were measured. At the same time, the transcription of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and the morphology of liver tissue were detected. Finally, the expression of related proteins (IRS, Akt) in the pathway of glucose and lipid metabolism was detected. The results showed that MXP could obviously resist mice body weight quick increase, MXP could significantly reduce the levels of TG, TC and LDL-C in the serum, TG and TC in liver, and increased the level of HDL-C in mice. MXP also could reduce the inflammatory cytokines including IL-6 and TNF-α and liver injury. Furthermore, MXP could improve the expression of IR and IRS significantly. The MXP seemed to improve the utilization rate of glucose and reduce the levels of inflammatory cytokines in liver, it has the potential to develop into a functional food and health care product. This study provides theoretical basis for scientific and rational development of M. xiaojinensis.
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