Abstract：Abstract Long non-coding RNA (lncRNA) is defined as a class of long transcripts longer than 200 nucleotides which are not translated into protein. They were considered as dark matter of products in gene expression at the beginning. lncRNA plays an important role in diseases, cell cycle, stem cells differentiation and so on. The correlative molecular mechanisms are generally classified four types (signals, guides, decoys and scaffolds). Because of the huge quantities and complex mechanisms of long non-coding RNAs, this research field still needs to be explored. In this review, we combine researches in recent years and summarize the definition, classification, molecular mechanisms, biological functions and prospect, This article provides reference for the study of the mechanisms and functions of lncRNA.
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