Effect of oleic acid on triglycerides (TG) accumulation and mRNA level of tumor necrosis factor α and peroxisome proliferator-activated receptor α in Goose Primary Hepatocytes
Abstract：In this study, the effect of oleic oil on cytoactive, triglycerides (TG) accumulation, lipids drop and mRNA expression of tumor necrosis factor α（TNFα） and peroxisome proliferator-activated receptor α（PPARα） was measured in primary goose hepatocytes. Results were as follows: 1.5 mmol/L oleic oil had an inhibiting effect on the cell viability; 1.5 mmol/L oleic oil could induce the goose hepatocytic steatosis and the increase of TG content and lipids drop. 0.5，1.0 and 1.5 mmol/L oleic oil all could increase the mRNA level of PPARα; 0.5 and 1.0 mmol/L oleic oil could increase the mRNA level of TNFα, but 1.5 mmol/Loleic oil had no evident effect, demonstrating that the expression of PPARα and TNFα in mRNA level is important for the balance of lipid metabolism in goose hepatocyte.
