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2025年4月5日 星期六
农业生物技术学报  2021, Vol. 29 Issue (8): 1622-1629    DOI: 10.3969/j.issn.1674-7968.2021.08.019
  研究评述与展望 本期目录 | 过刊浏览 | 高级检索 |
减毒单增李斯特菌为载体的肿瘤免疫治疗研究进展
陈璐1,*, 汪枫婷1,*, 孙静1,2,3, 陈中炜1,2,3, 卫芳芳1,2,3, 宋厚辉1,2,3,**, 程昌勇1,2,3,**
1 浙江农林大学 动物科技学院·动物医学院,杭州 311300;
2 浙江省畜禽绿色生态健康养殖应用技术研究重点实验室,杭州 311300;
3 动物健康互联网检测技术浙江省工程实验室,杭州 311300
Research Advances on Attenuated Listeria monocytogenes as a Vaccine Platform for Cancer Immunotherapy
CHEN Lu1,*, WANG Feng-Ting1,*, SUN Jing1,2,3, CHEN Zhong-Wei1,2,3, WEI Fang-Fang1,2,3, SONG Hou-Hui1,2,3,**, CHENG Chang-Yong1,2,3,**
1 College of Animal Science and Technology·College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China;
2 Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Hangzhou 311300, China;
3 Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, Hangzhou 311300, China
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摘要 单增李斯特菌(Listeria monocytogenes)是重要的人兽共患食源性胞内寄生菌,孕妇、儿童、老年人等免疫力低下者为易感人群,严重时可导致死亡。单增李斯特菌由于其独特的胞内感染特性可作为载体携带肿瘤相关抗原,感染机体后能刺激免疫系统产生强烈的细胞免疫反应,从而识别并清除肿瘤,越来越多研究证实李斯特菌有望成为肿瘤免疫治疗的理想工具。目前已经利用减毒单增李斯特菌作为载体开发了针对多种恶性肿瘤的疫苗,如宫颈癌疫苗、犬骨肉瘤疫苗,在临床试验中也表明了李斯特菌疫苗的有效性。本文对李斯特菌在肿瘤免疫治疗中的研究及临床试验进展进行了系统综述,有助于读者了解目前肿瘤治疗疫苗研究领域的最新技术和发展前景,为有效开发针对肿瘤防治的新策略和新技术提供了参考。
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陈璐
汪枫婷
孙静
陈中炜
卫芳芳
宋厚辉
程昌勇
关键词 减毒单增李斯特菌细胞免疫疫苗载体肿瘤免疫治疗    
AbstractListeria monocytogenes is a Gram-positive facultative intracellular bacterial pathogen that can infect humans and animals, causing listeriosis in neonates, pregnant women, elderly persons, and individuals whose immune system is compromised. Live L. monocytogenes is adept at generating strong antigen-specific T-cell responses due to its unique features during host infection, making it an attractive vector for cancer immunotherapy. Increasing studies have shown that the attenuated Listeria is becoming an efficient tool for cancer immunotherapy. Several Listeria-based tumor vaccines undergo being developed, such as the cervical cancer and canine osteosarcoma. Clinical trials have exhibited impressive therapeutic efficacy in these cancer models. This review will summarize the recent studies and progress about Listeria-based cancer immunotherapy, which will help readers understand the current technology and development of tumor immunotherapy vaccines. This review could provide a reference for developing new strategies and technologies for tumor prevention and treatment.
Key wordsAttenuated Listeria monocytogenes    Cellular immunity    Vaccine platform    Cancer    Immunotherapy
收稿日期: 2020-11-20     
ZTFLH:  S857.4R73  
基金资助:国家自然科学基金项目(31972648, 31872620和31770040); 浙江省自然科学基金项目(LZ19C180001; LQ19C180002; LQ20C010001); 浙江省高校基础研究基金(2020KJ004)
通讯作者: ** lamge@zafu.edu.cn;songhh@zafu.edu.cn   
作者简介: * 同等贡献作者
引用本文:   
陈璐, 汪枫婷, 孙静, 陈中炜, 卫芳芳, 宋厚辉, 程昌勇. 减毒单增李斯特菌为载体的肿瘤免疫治疗研究进展[J]. 农业生物技术学报, 2021, 29(8): 1622-1629.
CHEN Lu, WANG Feng-Ting, SUN Jing, CHEN Zhong-Wei, WEI Fang-Fang, SONG Hou-Hui, CHENG Chang-Yong. Research Advances on Attenuated Listeria monocytogenes as a Vaccine Platform for Cancer Immunotherapy. 农业生物技术学报, 2021, 29(8): 1622-1629.
链接本文:  
http://journal05.magtech.org.cn/Jwk_ny/CN/10.3969/j.issn.1674-7968.2021.08.019     或     http://journal05.magtech.org.cn/Jwk_ny/CN/Y2021/V29/I8/1622
 
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