GDF8在生殖系统的功能研究进展

doi:10.3969/j.issn.1674-7968.2021.07.016

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摘要生长分化因子8 (growth differentiation factor 8, GDF8)基因是转化生长因子β (transforming growth factor-β, TGF-β)超家族的成员之一,除了作为肌肉生长负调节剂外,还在脂质代谢、糖代谢等多种生物学过程中发挥功能,目前对其在生殖系统中的作用研究日渐增多。研究发现,GDF8及其受体在子宫、卵巢、输卵管、胚胎等组织中均有表达并发挥重要的生理作用,包括参与卵泡发育和排卵,调控卵泡类固醇激素的合成,影响细胞外基质的形成以及颗粒细胞的增殖、分化和扩散,与妊娠结果密切相关等。本文将结合国内外文献资料,综述GDF8在生殖系统中的研究进展,以期为后续研究提供参考。

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	任雪华
	雷安民

关键词 ： GDF8, 生殖系统, 功能

Abstract：The growth differentiation factor 8 (GDF8) gene is a member of the transforming growth factor-β(TGF-β) superfamily. In addition to acting as a negative regulator of muscle growth, it also functions in various biological processes such as lipid metabolism and sugar metabolism. Recently, the functional role of GDF8 in reproductive organs has received increased interest. Studies have found that GDF8 and its receptors are expressed in uterus, ovaries, fallopian tubes, embryos and other tissues and play important physiological roles, including participating in follicular development and ovulation, regulating the synthesis of follicular steroid hormones, affecting the formation of extracellular matrix and the proliferation, differentiation and diffusion of granular cells, and is closely related to the outcome of pregnancy. This article will review the research progress of GDF8 in the reproductive system based on domestic and foreign literature, in order to provide a reference for subsequent research.

Key words： GDF8 Reproductive system Function

收稿日期: 2020-08-03

ZTFLH:

S857.2

通讯作者: *anminleiryan@nwsuaf.edu.cn

引用本文:

任雪华, 雷安民. GDF8在生殖系统的功能研究进展[J]. 农业生物技术学报, 2021, 29(7): 1400-1406.
REN Xue-Hua, LEI An-Min. Research Progress of GDF8 Function in Reproductive System. 农业生物技术学报, 2021, 29(7): 1400-1406.

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http://journal05.magtech.org.cn/Jwk_ny/CN/10.3969/j.issn.1674-7968.2021.07.016 或 http://journal05.magtech.org.cn/Jwk_ny/CN/Y2021/V29/I7/1400

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