Research Progress of Long Non-coding RNA in Intestinal Diseases of Livestock and Poultry
GAO Xiao-Li1, HUANG Xiao-Yu1, YANG Qiao-Li1, ZHANG Sheng-Wei2, GUN Shuang-Bao1,2,*
1 College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China; 2 Gansu Research Center for Swine Production Engineering and Technology, Lanzhou 730070, China
Abstract：Long non-coding RNA (lncRNA) is an important class of functional non-coding RNA, which can regulate physiological processes such as cell proliferation, differentiation and metabolism, and participate in the regulation of various pathological processes in the body. In the rapid development of the intensive breeding industry, the intestinal diseases of livestock and poultry have a high incidence and mortality that seriously affect the health of livestock and poultry and cause significant economic losses to animal production industry. In recent years, many lncRNAs associated with intestinal inflammation and diseases have been identified by transcriptome sequencing technology. Researches on human (Homo sapiens) and mouse (Mus musculus) model organisms demonstrated that multiple lncRNAs are abnormally expressed in intestinal diseases, which regulate the expression and distribution of tight junction proteins, and also participate in the production of various inflammatory molecules and the activation of signaling pathways. In this paper, the regulatory function of lncRNA in intestinal barrier and immune-homeostasis, and the recent research progresses in livestock and poultry were reviewed. This review offers references for the follow-up research on resistance to intestinal diseases in livestock and poultry and the breeding of resistant varieties.
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