Abstract：Platelet-derived growth factor-D (PDGF-D) is a new member of PDGF family, it can regulate many biological processes, including angiogenesis, tissue fibrosis, tumorigenesis and lipid metabolism. It was found that PDGF-D is closely related to the sheep (Ovis aries) tail fat deposition and tail type, this gene could be used as candidate gene for tail type selection. PDGF-D can specifically bind to and activate its cognate receptor PDGFRβ (platelet-derived growth factor receptor β), then regulate many cellular processes, including cell proliferation, differentiation and apoptosis. This review introduced the discovery, structure, expression, physiological function and signal transduction pathway of PDGF-D gene, proposed the research emphasis of PDGF-D gene in the future. This article provides a valuable reference for PDGF-D gene research.
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