Abstract：Chemosensory proteins(CSPs) widely express in insect organs. Since its first being identified in Drosophila melanogaster, it has been identified from almost all insects. CSPs had been suggested to evolve from the same ancestor because gene clusters of CSP had been found in many species of animals. This review summarized the physical and chemical characters, expression features, molecule structures and evolution modes of CSPs, focused on their functions. Finally, a new functional view of CSPs has been proposed on the basis of previous study, including our lab's study, which is as protector and transfer of small molecules that are involved in metabolism.
[1]Ban L, Scaloni A, Brandazza A, Angeli S, Zhang L, Yan Y and Pelosi P.Chemosensory proteins of Locusta migratoria[J].Insect Molecular Biology, 2003, 12(2):125-134
[2]Briand L, Swasdipan N, Nespoulous C, Bézirard V, Blon F, Huet JC, Ebert P and Penollet JC.Characterization of a chemosensory protein (ASP3c) from honeybee (Apis mellifera L.) as a brood pheromone carrier [J].European Journal of Biochemistry, 2002, 269(18):4586-4596
[3]Campanacci V, Lartigue A, H?llberg BM, Jones TA, Giudici-Orticoni MT, Tegoni M and Cambillau C.Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding [J].Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(9):5069-5704
[4]Dani FR, Michelucci E, Francese S, Mastrobuoni G, Cappellozza S, La Marca G, Niccolini A, Felicioli A, Moneti G and Pelosi P.Odorant-binding proteins and chemosensory proteins in pheromone detection and release in the silkmoth Bombyx mori [J].Chemical Senses, 2011, 36(4):335-344
[5]Danty E, Briand L, Michard-Vanhée C, Perez V, Arnold G, Gaudemer O, Huet D, Huet JC, Ouali C, Masson C and Pernollet JC.Cloning and expression of a queen pheromone-binding protein in the honeybee: an olfactory-specific, developmentally regulated protein [J].The Journal of Neuroscience, 1999, 19(17):7468-7475
[6]Forêt S, Wanner KW and Maleszka R.Chemosensory proteins in the honey bee: Insights from the annotated genome, comparative analyses and expressional profiling [J].Insect Biochemistry and Molecular Biology, 2007, 37(1):19-28
[7]Gong DP, Zhang HJ, Zhao P, Lin Y, Xia QY and Xiang ZH.Identification and expression pattern of the chemosensory protein gene family in the silkworm, Bombyx mori [J].Insect Biochemistry and Molecular Biology, 2007, 37(3):266-277
[8]Gong L, Luo Q, Rizwan-ul-Haq M and Hu MY.Cloning and characterization of three chemosensory proteins from Spodoptera exigua and effects of gene silencing on female survival and reproduction [J].Bulletin of Entomological Research, 2012, 102(5):600-609
[9]González D, Zhao Q, McMahan C, Velasquez D, Haskins WE, Sponsel V, Cassill A and Renthal R.The major antennal chemosensory protein of red imported fire ant workers[J].Insect Molecular Biology, 2009, 18(3):395-404
[10]Guo W, Wang X, Ma Z, Xue L, Han J, Yu D and Kang L.CSP and takeout genes modulate the switch between attraction and repulsion during behavioral phase change in the migratory locust[J].PLoS Genetics, 2011, 7(2):e1001291-
[11]Guo Z, Cheng Zhu Y, Huang F, Luttrell R and Leonard R.Microarray analysis of global gene regulation in the Cry1Ab-resistant and Cry1Ab-susceptible strains of Diatraea saccharalis [J].Pest Management Science, 2012, 68(5):718-730
[12]Hu L, Shen J, Hu M, Rizwan-ul-Haq M and Hao W. Screening of T7 phage displayed Bactrocera dorsalis (Hendel) antenna cDNA library against chemosensory protein[J].Archives of Insect Biochemistry and Physiology, 2010, 75(3):174-186
[13]Jacquin-Joly E, Vogt RG, Fran?ois MC and Nagnan-Le Meillour P.Functional and expression pattern analysis of chemosensory proteins expressed in antennae and pheromonal gland of Mamestra brassicae [J].Chemical Senses, 2001, 26(7):833-844
[14]Jansen S, Chmelik J, Zidek L, Padrta P, Novák P, Zdráhal Z, Picimbon JF, Lofstedt C and Sklenár V.Structure of Bombyx mori chemosensory protein 1 in solution[J].Archives of Insect Biochemistry and Physiology, 2007, 66(3):135-145
[15]Jin X, Brandazza A, Navarrini A, Ban L, Zhang S, Steinbrecht RA, Zhang L and Pelosi P.Expression and immunolocalisation of odorant-binding and chemosensory proteins in locusts [J].Cellular and Molecular Life Sciences, 2005, 62(10):1156-1166
[16]Kamikouchi A, Morioka M and Kubo T.Identification of honeybee antennal proteins/genes expressed in a sex-and/or caste selective manner [J].Zoological Science, 2004, 21(1):53-62
[17]Kitabayashi AN, Arai T, Kubo T and Natori S.Molecular cloning of cDNA for p10, a novel protein that increases in the regenerating legs of Periplaneta americana (American cockroach)[J].Insect Biochemistry and Molecular Biology, 1998, 28(10):785-790
[18]Lartigue A, Campanacci V, Roussel A, Larsson AM, Jones TA, Tegoni M and Cambillau C.X-ray structure and ligand binding study of a moth chemosensory protein[J].The Journal of Biological Chemistry, 2002, 277(35):32094-32098
[19]Leal WS.Odorant Reception in Insects: roles of receptors binding proteins, and degrading enzymes [J].Annual Review of Entomology, 2013, 58:373-391
[20]Li X, Lu D, Liu X, Zhang Q and Zhou X.Ultrastructural characterization of olfactory sensilla and immunolocalization of odorant binding and chemosensory proteins from an ectoparasitoid Scleroderma guani (Hymenoptera: Bethylidae)[J].International Journal of Biological Sciences, 2011, 7(6):848-868
[21]Liu X, Luo Q, Zhong G, Rizwan-Ul-Haq M and Hu M.Molecular characterization and expression pattern of four chemosensory proteins from diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae)[J].Journal of Biochemistry, 2010, 148(2):189-200
[22]Maleszka J, Forêt S, Saint R and Maleszka R.RNAi-induced phenotypes suggest a novel role for a chemosensory protein CSP5 in the development of embryonic integument in the honeybee (Apis mellifera)[J].Development Genes and Evolution, 2007, 217(3):189-196
[23]Oduol F, Xu J, Niare O, Natarajan R and Vernick KD.Genes identified by an expression screen of the vector mosquito Anopheles gambiae display differential molecular immune response to malaria parasites and bacteria[J].Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(21):11397-11402
[24]Pelosi P, Calvello M and Ban L.Diversity of odorant-binding proteins and chemosensory proteins in insects[J].Chemical Senses, 2005, 30 suppl 1: i291-i292
[25]Sabatier L, Jouanguy E, Dostert C, Zachary D, Dimarcq JL, Bulet P and Imler JL.Pherokine-2 and -3[J].European Journal of Biochemistry, 2003, 270(16):3398-3407
[26]Sánchez-Gracia A, Vieira FG, Almeida FC and Rozas J.Comparative Genomics of the Major Chemosensory Gene Families in Arthropods[J]., 2011, :-
[27]Sánchez-Gracia A, Vieira F and Rozas J.Molecular evolution of the major chemosensory gene families in insects[J].Heredity, 2009, 103(3):208-216
[28]Steller MM, Kambhampati S and Caragea D.Comparative analysis of expressed sequence tags from three castes and two life stages of the termite Reticulitermes flavipes[J].BMC Genomics, 2010, 11:463-
[29]Strandh M, Johansson T, Ahrén D and Lofstedt C.Transcriptional analysis of the pheromone gland of the turnip moth, Agrotis segetum (Noctuidae), reveals candidate genes involved in pheromone production[J].Insect Molecular Biology, 2008, 17(1):73-85
[30]Tomaselli S, Crescenzi O, Sanfelice D, Ab E, Wechselberger R, Angeli S, Scaloni A, Boelens R, Tancredi T, Pelosi P and Picone D.Solution structure of a chemosensory protein from the desert locust Schistocerca gregaria [J].Biochemistry, 2006, 45(35):10606-10613
[31]Vieira FG and Rozas J.Comparative genomics of the odorant-binding and chemosensory protein gene families across the Arthropoda: origin and evolutionary history of the chemosensory system[J].Genome Biology and Evolution, 2011, 3:476-490
[32]Vigneron A, Charif D, Vincent-Monégat C, Vallier A, Gavory F, Wincker P and Heddi A.Host gene response to endosymbiont and pathogen in the cereal weevil Sitophilus oryzae. [J].BMC Microbiology, 2012, 12 Suppl 1:S14-
[33]Vincent B, Kaeslin M, Roth T, Heller M, Poulain J, Cousserans F, Schaller J, Poirié M, Lanzrein B, Drezen JM and Moreau SJ.The venom composition of the parasitic wasp Chelonus inanitus resolved by combined expressed sequence tags analysis and proteomic approach[J].BMC Genomics, 2010, 11:693-
[34]Vogt RG, ed.Biochemical diversity of odor detection: OBPs, ODEs and SNMPs[J].Elsevier, Amsterdam, 2003, :391-445
[35]Wanner KW, Isman MB, Feng Q, Plettner E and Theilmann DA.Developmental expression patterns of four chemosensory protein genes from the Eastern spruce budworm, Chroistoneura fumiferana[J].Insect Molecular Biology, 2005, 14(3):289-300
[36]Wanner KW, Willis LG, Theilmann DA, Isman MB, Feng Q and Plettner E.Analysis of the insect os-d-like gene family[J].Journal of Chemical Ecology, 2004, 30(5):889-911
[37]Yoshizawa Y, Sato R, Tsuchihara K, Ozaki K, Mita K, Asaoka K and Taniai K.Ligand carrier protein genes expressed in larval chemosensory organs of Bombyx mori[J].Insect Biochemistry and Molecular Biology, 2011, 41(8):545-562
[38]Zhang S, Zhang YJ, Su HH, Gao XW and Guo YY.Identification and expression pattern of putative odorant-binding proteins and chemosensory proteins in antennae of the Microplitis mediator (Hymenoptera: Braconidae) [J].Chemical Senses, 2009, 34(6):503-512
[39]Zhou JJ, Kan Y, Antoniw J, Pickett JA and Field LM.Genome and EST analyses and expression of a gene family with putative functions in insect chemoreception[J].Chemical Senses, 2006, 31(5):453-465
