Abstract：To evaluate the safety of transgenic herbicide-resistant maize, the transgenic maize and its non-transgenic counterpart were fed to Sprague-Dawley(SD) rats(Rattus norvegicus) during 90 d. This study added the genetically modified(GM) maize(CC-2) and its non-transgenic control maize(Zheng-58) in a ratio of 12.5%, 25.0% and 50.0% respectively to the basal feed. The influence and safety of GM maize were evaluated by monitoring SD rats' nutrition, physiological status, and biochemical indicators. During the 90 d feeding for SD rats, we surveyed the nutritional status of SD rats and the effects of physiological indexes, such as body weight, hematology and serum biochemistry indexes. At the end of the study, we dissected the animals for pathological observation and calculated viscera coefficient. After 90 days, animals of each group were in good condition. Compared with the non-GM maize control group, several indexes of the serum biochemistry, hematology, relative organ weight of SD rats fed on GM corn had statistically significant difference(P＜0.05) and no dose-relative or gender-relative. So it had no biological significance. The transgenic herbicide-resistant maize is as same safety as its non-GM maize in 90 d feeding study. This study provides scientific evidence for the safe usage of GM maize.
