Research Progress on Candidate Genes for Disease Resistance Breeding in Pigs (Sus scrofa)
YANG Song-Bai1, HUANG Jing2, DUAN Xing1, WANG Han1, ZHOU Xiao-Long1,*, ZHAO A-Yong1,*
1 Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology•College of Veterinary Medicine, Zhejiang A&F University, Lin'an 311300, China;
2 Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China
Abstract：Disease-resistant breeding is a crucial strategy to enhance the resilience of pig (Sus scrofa) populations against pathogen infections. The success of this approach relies on the comprehensive identification and investigation of candidate genes associated with disease resistance in the host. Therefore, identifying high-quality candidate genes is essential for disease-resistant breeding. This review summarized recent progress in research on candidate genes related to resistance against several significant viral infectious diseases in pigs, including Porcine reproductive and respiratory syndrome virus (PRRSV), African swine fever virus (ASFV), Classical swine fever virus (CSFV), Porcine epidemic diarrhea virus (PEDV), Pseudorabies virus (PRV), and Japanese encephalitis virus (JEV). Furthermore, the review discussed the challenges associated with the study of candidate genes for disease resistance and their application in breeding practices, and provides valuable insights for swine disease-resistant breeding research and practice in China.
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