Advances in the Regulation of Mammalian Myogenesis and Adipose Development by Histone Modifications
LIU Yue1, DU Shu-Zeng2, YANG Hai-Yan1, PAN Ye-Jun1, PAN Chuan-Ying1, LAN Xian-Yong1,*
1 College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China; 2 Nanyang Vocational College of Agriculture, Nanyang 473000, China
Abstract：Epigenetics mainly studies the heritable changes in gene function that lead to phenotypic changes in the absence of alterations in DNA sequence, and is essentially a change in chromatin state. As an important part of epigenetic research, histone modifications play an important role in maintaining the genome stability, gene expression regulation and chromatin structure of eukaryotes. Their essence is the process of methylation, acetylation and ubiquitination under the action of related enzymes. Histone modifications are variety of various biological processes that regulate the development of tissues and organs. Mesenchymal stem cells (MSCs) are important members of the animal stem cell family and important sources of animal myogenic and adipogenic cells, and the lineage differentiation of MSCs is accompanied by reprogramming of gene expression, a process largely dependent on epigenetic regulation. Histone methylation and acetylation modification regulators act as a bridge between signal transduction and downstream gene reprogramming, playing a crucial role in the epigenetic remodeling of cell differentiation. This paper reviewed the types and mechanisms of histone modifications, and recent advances in the study of histone modifications on animal myogenesis and adipogenesis. This review provides a reference for exploring the mechanism of mesenchymal stem cell differentiation and provides a theoretical basis for further improving mammalian muscle quality.
刘悦, 杜书增, 杨海焱, 潘晔君, 潘传英, 蓝贤勇. 组蛋白修饰调控动物肌肉生成与脂肪发育的研究进展[J]. 农业生物技术学报, 2024, 32(7): 1660-1668.
LIU Yue, DU Shu-Zeng, YANG Hai-Yan, PAN Ye-Jun, PAN Chuan-Ying, LAN Xian-Yong. Advances in the Regulation of Mammalian Myogenesis and Adipose Development by Histone Modifications. 农业生物技术学报, 2024, 32(7): 1660-1668.
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