Abstract：In mammalian spermatogenesis, spermatogonial stem cells (SSCs) possess the characteristics of stem cells or progenitor cells. SSCs can not only conduct self-renewal to maintain the stem cell pool, but also conduct differentiation to maintain the continuous production of sperm. Therefore, the regulatory mechanism of self-renewal and differentiation of SSCs is crucial for the development of male germ cells. At present, the regulation of SSCs has become an important topic in the reproduction and stem cell research. As a multifunctional transcription factor, the highly conserved promyelocytic leukemia zinc finger (PLZF) protein has been proved to be necessary for the self-renewal of SSCs. This review focuses on the advances of biological characteristics and functions of PLZF, and the regulatory mechanism of PLZF on SSCs, which will provid a reference for exploring the gene regulatory network of PLZF and its role in the development of male germline stem cells (mGSCs).
闫慧敏, 李雪玲. PLZF蛋白在精原干细胞自我更新与分化中作用的研究进展[J]. 农业生物技术学报, 2023, 31(11): 2411-2422.
YAN Hui-Min, LI Xue-Ling. Research Progress on the Role of PLZF Protein in Self-renewal and Differentiation of Spermatogonial Stem Cells. 农业生物技术学报, 2023, 31(11): 2411-2422.
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