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2025年8月15日 星期五
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鸡C/EBPα基因的多态性与生长和体组成性状的相关研究
张爱朋1,王守志1,王启贵1,胡晓湘1,李辉2
1.
2. 东北农业大学动物科学学院
Polymorphisms of C/EBPα Gene Associated with Growth and Body Composition Traits in Chickens
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摘要 摘 要 CCAAT增强子结合蛋白α(CCAAT/enhancer-binding protein α,C/EBPα)在脂肪细胞分化过程中起重要作用,是生长和体组成性状的重要候选基因。以东北农业大学肉鸡(Gallus gallus)高、低腹脂双向选择品系的第9、10世代肉仔鸡为材料,采用测序方法对鸡C/EBPα基因的部分5′侧翼区、编码区和部分3′侧翼区序列进行多态性检测,研究该基因多态性与鸡生长和体组成性状之间的关系。研究发现在C/EBPα基因编码区552 bp位置存在一个沉默突变c.*552G>A。统计分析结果表明,该突变对肉鸡的腹脂重、腹脂率、肝脏重、肝脏率、胫围、胫骨重等性状具有显著影响(P<0.05)。相对于GG基因型个体,AA基因型个体具有较高的腹脂重和腹脂率(P<0.05);对于肝脏重、肝脏率、胫围、胫骨重等性状,GG基因型个体则显著高于AA基因型个体(P<0.05)。初步推断C/EBPα基因可能是控制腹脂沉积、骨骼生长发育的主效基因或与主效基因紧密连锁。
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张爱朋
王守志
王启贵
胡晓湘
李辉
关键词 C/EBPαSNP脂肪骨骼主效基因    
Abstract:Abstract CCAAT/enhancer-binding protein α(C/EBPα) gene plays a key role in the process of adipocyte differ- entiation, which is also an important candidate gene for growth and body composition traits. In the current study, polymorphisms of 5′region, coding sequence and 3′region of C/EBPα were detected by sequencing the 9th and 10th population of a designed resource population, the Northeast Agricultural University broiler lines (Gallus gallus) divergently selected for abdominal fat percentage (NEAUHLF). A silent mutation (c.*552G>A) was found at base 552 of the coding sequence. Association analysis indicated that the mutation was significantly related to abdominal fat weight, abdominal fat percentage, liver weight, liver weight percentage, metatarsus circle and shank weight (P<0.05). The abdominal fat weight and abdominal fat percentage of birds with AA genotype were significantly higher than those with GG genotype (P<0.05), and the liver weight, liver weight percentage, metatarsus circle and shank weight femur length of birds with GG genotype were significantly higher than those with AA genotype (P<0.05). The conclusion was drawn that C/EBPα gene can be or link to a major gene that affects fat deposition and skeletal development traits in chickens.
Key wordschicken    C/EBPα    SNP    fat    skeleton    major gene
收稿日期: 2009-04-16     
通讯作者: 李辉   
引用本文:   
张爱朋1,王守志1,王启贵1,胡晓湘1,李辉2. 鸡C/EBPα基因的多态性与生长和体组成性状的相关研究[J]. , 2010, 18(4): 746-752.
链接本文:  
http://journal05.magtech.org.cn/Jwk_ny/CN/     或     http://journal05.magtech.org.cn/Jwk_ny/CN/Y2010/V18/I4/746
 
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