Abstract：Abstract Cypermethrin(CYP) has deleterious effects on male reproductive function. The objective of this study was to identify whether the effects of β-CYP on sertoli cells dedifferentiation were associated with oxidative stress. A dose of β-CYP(20 mg/kg) was administered to male mice(Mus culus) for 35 d with or without vitamin E(20 mg/kg). The expression and distribution of proliferating cell nuclear antigen(PCNA) and connexin 43(CX43) in testes were detected by immunohistochemistry and the testis total antioxidant capacities were detected. β-CYP not only increaed the expression of PCNA in sertoli cells,but also decreased the expression of CX43 in sertoli cells and total antioxidant capacity(TAC)(P<0.05). Vitamin E reversed the effects of β-CYP on he expression of PCNA and CX43 in sertoli cells and total antioxidant capacity(P <0.05). Therefore, β-CYP can cause sertoli cells dedifferentiation by inducing oxidative stress.
