Abstract：Chromosome missegregation in mammalian oocytes and early embryos leads to embryo aneuploidy and early pregnancy loss. In mitotic cells, the microtubules that compose the spindle are mostly nucleated and bipolarized by centrosomes acting as major microtubule organizing centers (MTOCs). However, mammalian oocytes remove their centrosomes for reasons that are still speculative. Spindle assembly needs suppletive pathways (including RanGTP pathway, Augmin pathway and CPC pathway). This paper illuminated the centrosome-independent spindle assembly and related processes in mammalian oocytes, and discussed the differences in spindle assembly and the relationship between spindle assembly and aneuploidy in different mammalian oocytes. This paper provides reference for the mechanism of mammalian aneuploid formation and chromosome aberration.
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