Abstract：With the rapid development of molecular biology techniques, animal breeding has entered the era of molecular breeding guided by quantitative genetics, molecular genetics and other disciplines. Animal biology breeding exhibits significant application value and industrial prospects, and will be helpful to promote the localization process of livestock and poultry breeding in China. This review summarized the development history, research progress and applications of animal biology breeding around the world, including genomic selection and genome editing, etc. It also analyzed the development status of the existing problems in China's animal biology breeding in the perspective of technological innovations and technological industrialization, and also put forth the countermeasures and proposals for promoting animal breeding industry, including strengthening independent innovation research.
[1] 朱作言, 许克圣, 谢岳峰, 等. 1989. 转基因鱼模型的建立[J]. 中国科学(B辑 化学 生命科学 地学), 02: 147-155.(Zhu Z Y, Xu K S, Xie Y F, et al. 1989. Model building of Transgenic fish[J]. Science in China (B Series Chemistry Life Science Earth Science), 02:147-155.)[2] Anguela X M, Sharma R, Doyon Y, et al. 2013. Robust ZFN-mediated genome editing in adult hemophilic mice[J]. Blood, 122(19): 3283-7.[3] Berry D, Kearney F, Harris B. 2009. Genomic selection in Ireland[J]. Interbull Bulletin, 39: 29–34.[4] Carlson D F, Tan W, Lillico S G, Stverakova D, et al. 2012. Efficient TALEN-mediated gene knockout in livestock[J]. Proceedings of the National Academy of Sciences of the United States of America, 109(43): 17382–17387.[5] Christian M, Cermak T, Doyle E L, et al. 2010. Targeting DNA double-strand breaks with TAL effector nucleases[J]. Genetics, 186: 757-61.[6] Cui C, Song Y, Liu J, et al. 2015. Gene targeting by TALEN-induced homologous recombination in goats directs production of beta-lactoglobulin-free, high-human lactoferrin milk[J]. Scientific Reports, 5: 10482.[7] Daetwyler H D, Hickey J M, Henshall J M, et al. 2010. Accuracy of estimated genomic breeding values for wool and meat traits in a multibreed sheep population[J]. Animal Production Science, 50: 1004–1010.[8] De Roos A P W, Schrooten C, Mullaart E, et al. 2009. Genomic selection at CRV[J]. Interbull Bull, 2009, 39: 47–50.[9] Deng S, Li G,Zhang J, et al. 2013. Transgenic cloned sheep overexpressing ovine toll-like receptor 4[J]. Theriogenology, 80(1): 50-7.[10] Gonzalez-Recio O, Gianola D, Rosa G J, et al. 2009. Genome-assisted prediction of a quantitative trait measured in parents and progeny: Application to food conversion rate in chickens[J]. Genetics Selection Evolution, 41: 3.[11] Gupta A, Christensen R G, Rayla A L, et al. 2012. An optimized two-finger archive for ZFN-mediated gene targeting[J]. Nature Methods, 9: 588-90.[12] Habier D, Tetens J, Seefried F R, et al. 2010. The impact of genetic relationship information on genomic breeding values in German Holstein cattle[J]. Genetics Selection Evolution, 42: 5.[13] Harris B L, Montgomerie W A. 2009. Current status of the use of genomic information in the national genetic evaluation in New Zealand[J]. Interbull Bulletin，Interbull: Uppasla, Sweden. 35–38.[14] Hauschild-Quintern J, Petersen B, Queisser A L, et al. 2013. Gender non-specific efficacy of ZFN mediated gene targeting in pigs[J]. Transgenic Research, 22: 1-3.[15] Hayes B, Bowman P, Chamberlain A, et al.2009. Accuracy of genomic breeding values in multi-breed dairy cattle populations[J]. Genetics Selection Evolution, 41: 51.[16] Ju H, Zhang J, Bai L, et al. 2015. The transgenic cloned pig population with integrated and controllable GH expression that has higher feed efficiency and meat production[J]. Scientific Reports, 5: p. 10152.[17] Whitworth K M, Lee K, Benne J A, et al. 2014. Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos[J]. Biology of Reproduction, 91(3): 78.[18] Li P, Estrada J L, Burlak C, et al. 2015. Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection[J]. Xenotransplantation, 22(1): 20-31.[19] Liu X, Wang Y, Tian Y, et al. 2014. Generation of mastitis resistance in cows by targeting human lysozyme gene to beta-casein locus using zinc-finger nucleases[J]. Proceedings Biological sciences, 281(1780): p. 20133368.[20] Liu X, Wang Y, Guo W, et al. 2013. Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows[J]. Nature Communications, 4: p. 2565.[21] Luan T, Woolliams J A, Lien S, et al. 2009. The accuracy of genomic selection in Norwegian red cattle assessed by cross-validation[J]. Genetics, 183: 1119–1126.[22] Lund M S, Roos A P W D, Vries A G D, et al. 2010. Improving genomic prediction by EuroGenomics collaboration[J]. In: 9th World Conference of Genetics Applied on Livestock Production, Leipzig, Germany. 880[23] Lund M S, Su G. 2009. Genomic selection in the Nordic countries[J]. Interbull bulletin, 39: 39–42.[24] Luo J, Song Z, Yu S, Cui D, et al. 2014. Efficient generation of myostatin (MSTN) biallelic mutations in cattle using zinc finger nucleases[J]. PLos One, 9:i. e95225.[25] Maeder M L, Thibodeau-Beganny S, Osiak A, et al. 2008. Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification[J]. Molecular Cell, 31: 294-301.[26] Maeder M L, Thibodeau-Beganny S, Sander J D, et al. 2009. Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays[J]. Nature Protocols, 4: 1471-501.[27] Mali P, Yang L, Esvelt K M, et al. 2013. RNA-guided human genome engineering via Cas9[J]. Science, 339: 823-6.[28] Meuwissen T H,Hayes B J, Goddard M E, et al. 2001. Prediction of total genetic value using genome-wide dense marker maps[J]. Genetics, 157: 1819–1829.[29] Moser G, Tier B, Crump R E, et al. 2009. A comparison of five methods to predict genomic breeding values of dairy bulls from genome-wide SNP markers[J]. Genetics Selection Evolution, 41: 56.[30] Ni W, Qiao J, Hu S, et al. 2014. Efficient gene knockout in goats using CRISPR/Cas9 system[J]. PloS One, 9: e106718.[31] Qian L, Tang M, Yang J, et al. 2015. Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs[J]. Scientific Reports,5: p. 14435.[32] Reyon D, Tsai S Q, Khayter C, et al. 2012. FLASH assembly of TALENs for high-throughput genome editing[J]. Nature Biotechnology, 30: 460-5.[33] Ruan J, Li H, Xu K, et al. 2015. Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs[J]. Scientific Reports, 5: p. 14253.[34] Sander J D, Dahlborg E J, Goodwin M J, et al. 2011. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)[J]. Nature Methods, 8: 67-9.[35] VanRaden P M, Van Tassell C P, Wiggans G R, et al. 2009. Reliability of genomic predictions for North American Holstein bulls[J]. Journal of Dairy Science, 92: 16–24.[36] Verbyla K L, Hayes B J, Bowman P J, et al. 2009. Accuracy of genomic selection using stochastic search variable selection in Australian Holstein Friesian dairy cattle[J]. Genetics and Molecular Research, 91: 307–311.[37] Wang J, Exline C M, DeClercq J J, et al. 2015. Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors[J]. Nature Biotechnology, doi: 10.1038/nbt.3408[38] Wolc A, Stricker C, Arango J, et al. 2011. Breeding value prediction for production traits in layer chickens using pedigree or genomic relationships in a reduced animal model[J]. Genetics Selection Evolution, 43: 5.[39] Wu H, Wang Y, Zhang Y, et al. 2015. TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis[J]. Proceedings of the National Academy of Sciences of the United States of America,112(13):E1530-9.[40] Yu S, Luo J, Song Z, et al.2011. Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle[J]. Cell Research, 21(11): p. 1638-40[41] Crispo M, Mulet A P, Tesson L, et al. 2015. Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology andMicroinjection into Zygotes[J]. PLoS One, 10(8):e0136690.
