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五指山小型猪近交系培育与遗传资源创新
冯书堂1,李奎 2,牟玉莲1,杨述林2
1. 中国农业科学院畜牧研究
2. 中国农业科学院北京畜牧兽医研究所
Inbreeding Line Culture of Wuzhishan Mini-pig and the Innovation in Nurturing Inbred for Chinese Genetic Resources
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摘要 中国农业科学院北京畜牧兽医研究所二十多年来,利用2头五指山小型猪(Sus scrofa)(Wuzhishan mini-pig,WZSP),采用近交繁育,培育出近交系,最高已获得近交F22,并进行开发应用。对WZSP近交系全基因组测序并与人(Homo sapiens)、短尾猴(Macaque mulatta)和大鼠(Rattus norvegicus)比对,初步分析发现,该近交系全基因组具有较高的纯合度和特异的分子遗传特征,不仅证明了我国实现遗传资源创新培育近交系的可靠性,而且证明该近交系猪是人类理想的“替难者”。实现我国小型猪遗传资源创新的培育目标,取得了一定的经济和较大社会效益,有着重要的现实和历史意义
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冯书堂
李奎
牟玉莲
杨述林
关键词 五指山小型猪近交系全基因组遗传资源    
Abstract:Experimental animals are important research content of the research conditions. In past more than 20 years, the Wuzhishan mini-pig(Sus scrofa)(WZSP) inbred line has been carried out by Institute of Animal Science, Chinese Academy of Agricultural Sciences, with inbreeding heddle measure. Up to now, inbreeding F22 of pig's herd have been already obtained which has been applied on human medicine industry. Recently, the whole-genomesequencing of the inbred's WZSP was performed which would be inbred for medical experiments. Compared with human(Homo sapiens), macaque(Macaque mulatta) and rat(Rattus norvegicus), the genome of the inbred pig represented the high homozygosity and specific molecular genetic characteristics. In addition, results from the genome sequencing not only reveal reliability of the innovation in nurturing inbred for Chinese genetic resources, also imply that the inbred line pig is an ideal model in human medical research. The cultivation of Chinese miniature pigs has important practical and historical significance
Key wordsWuzhishan mini-pig    Inbreeding line    Whole-genome sequencing    Genetic resources
收稿日期: 2012-05-14     
通讯作者: 冯书堂   
引用本文:   
冯书堂1,李奎 2,牟玉莲1,杨述林2. 五指山小型猪近交系培育与遗传资源创新[J]. , 2012, 20(8): 849-857.
链接本文:  
http://journal05.magtech.org.cn/Jwk_ny/CN/     或     http://journal05.magtech.org.cn/Jwk_ny/CN/Y2012/V20/I8/849
 
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