Abstract：Avian is a valuable animal model, and plays a significant part in agriculture and biomedicine. In recent years, newly developed programmable gene editing tools such as TALEN and CRISPR/Cas9 have been successfully adopted in avian species. These gene modification technologies are expected to be applied to practical uses, such as enhancing economic traits of poultry, investigating virus-receptor interaction, developing vector vaccines, improving poultry welfare, and producing pharmaceutical proteins and antibodies in eggs, etc. In this review, we present a concise description of the existing approaches of genome editing in bird species, and the application of CRISPR/Cas9 in advancing poultry breeding and production, as well as in poultry research. In addition, we discuss the potential use of gene-edited poultry model in various industries in the future. This review will lead to improve economic traits of poultry and control avian viral diseases by means of gene editing techniques.
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