Application Progress of Gene Editing in Agricultural Animals
MA Yu-Hao1, GAO Shuang2, DONG Xiang-Hui2, LI Rui2, DENG Xue-Mei1,*
1 Laboratory of Animal Genetic Resources and Molecular Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; 2 Inner Mongolia Grassland Jinfeng Animal Husbandry Co., Ltd., Chifeng 025350, China
Abstract：Gene editing is a technology that precisely modifies endogenous genes in living organisms. From its appearance to the application, it has greatly promoted the development of agricultural science. The development of gene editing technology is divided into three main stages: the zinc finger nuclease (ZFN) stage, the transcription activation-like effector nuclease (TALEN) stage, and the clustered regularly interspaced short palindromic repeats (CRISPR) stage. Gene editing technology has the characteristics of specifically recognizing target sequences and targeted modification of targeted genes. This technology is applied to the verification of the main genes of key traits of agricultural animals, and the breeding process of agricultural animals is accelerated through precise editing of known functional genes. This review will focus on gene editing and its application in agricultural animals, and provide references for research in animal breeding and related fields.
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