Research Progress in Genomics and Functional Genes of Ganoderma lingzhi
XIE Xin1, HE Li-Ming1, CAI Ling1, LIU Lin-Qiu1, LUO Xia1,2*
1 Laboratory for Systemic Research and Development of Fungal Medicinal Materials, Institute of Fungal Medicinal Materials, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China; 2 Sichuan-Chongqing Joint Key Laboratory of Innovation of New Drugs of Traditional Chinese Medicine, Chengdu 610041, China
Abstract：Ganoderma lingzhi is a valuable edible and medicinal fungus, at present, there are more than 200 kinds of secondary metabolites isolated from various tissues of G. lingzhi, among which G. lingzhi triterpenoids and polysaccharides are its main active ingredients, and their pharmacological effects mainly include anti-hypertensive, anti-tumor, anti-aging, The completion of G. lingzhi genome sequencing and the establishment of genetic transformation system have gradually become a model fungus for the study of the synthesis and regulation of secondary metabolites of medicinal fungi, and its molecular biology research involves the identification of G. lingzhi germplasm resources, genetic diversity, variety breeding, functional gene cloning, etc.. In this paper, the research progress of G. lingzhi genomics, functional genes involved in the regulation of G. lingzhi growth and development, metabolite synthesis, abiotic stress and signal transduction were summarized, so as to provide a reference for the further development and application of G. lingzhi and a scientific basis for elucidating the molecular mechanism of G. lingzhi efficacy.
谢欣, 贺黎铭, 蔡凌, 刘林秋, 罗霞. 灵芝基因组学及其功能基因研究进展[J]. 农业生物技术学报, 2025, 33(4): 898-910.
XIE Xin, HE Li-Ming, CAI Ling, LIU Lin-Qiu, LUO Xia. Research Progress in Genomics and Functional Genes of Ganoderma lingzhi. 农业生物技术学报, 2025, 33(4): 898-910.
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