Abstract：Gene editing technology provides a new solution for pig (Sus scrofa) molecular breeding. Gene editing technology can achieve accurate and efficient gene editing, providing a powerful tool for breeding pig. Gene editing can not only be used to quickly and accurately improve growth rate and disease resistance, thereby enhancing the feeding efficiency of pigs, but also optimize the quality, taste and even nutritional content of pork to meet the growing consumer demand for high-quality, healthy pork. However, there are still many technical challenges in the application of gene editing technology, such as off-target effects. It is necessary to increase technological innovation to solve these problems restricting the efficiency of pig gene editing breeding, and promote the wide application of gene editing technology in pig disease resistance breeding. This paper summarized the latest development of gene editing technology in pig molecular breeding, including technical progress, application status and challenges. This review provides reference for breeding of disease resistance in China.
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