Research Progress on Mastitis Related Genes Regulation and Genetic Modification Models
QIU Shuang1, GUO Zi-Rong1, CHEN Li-Qiang1, ZHU Yi-Jing2, BAI Hui3, ZHANG Li-Guo2,*, SU Xiao-Hu1,*
1 Schoolof Life Sciences, Inner Mongolia University, Hohhot 010020, China; 2 Ulanqab Animal Husbandry Workstation of Inner Mongolia Autonomous Region, Ulanqab 012000, China; 3 Institute of Animal Husbandry, Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China
Abstract：Mastitis is one of the major threats that affects the production performance of dairy livestock. However, the traditional antibiotic application strategy would lead to drug residues and resistance. This review systematically summarized research progress on mastitis-regulating genes to explore novel prevention and treatment strategies, including inflammatory pathway genes (Toll-like receptor 4 (TLR4), nuclear factor-kappa B (NF-κB)), chemokine genes (interleukin-8 (IL-8), tumour necrosis factor-α (TNF-α)), antimicrobial genes (lysozyme (LYZ), β-defensin-4 (DEFB4), lactoferrin (LF)), and apoptosis-autophagy genes such as B cell lymphoma-2 (Bcl2), Bcl-2-associated X protein (BAX), autophagy-related gene 5 (ATG5), microRNA-223 (miR-223) and other apoptosis-autophagy genes. And this review summarized advances in genetic modification models for mastitis regulation, including mice (Mus musculus), dairy goats (Capra hircus), and dairy cows (Bos taurus). This review provides a technical reference for the novel breeding materials creation of mastitis-resistant dairy livestock and the theoretical guidance for the development of targeted prevention and control strategies for mastitis.
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