Research Progress on Reproductive Containment Technologies of Fish
TAO Bin-Bin, HU Wei*
Institute of Hydrobiology/State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture/Hubei Hongshan Laboratory, Chinese Academy of Sciences, Wuhan 430072, China
Abstract：Reproductive containment in farmed fish holds significant application potential in improving economic traits, ensuring the industrialization of biological breeding, and protecting intellectual property (IP). Currently, interspecific hybridization and triploid sterility methods have achieved success in the production of sterile broodstock for a limited number of farmed fish species. However, due to technical limitations, these approaches have not yet been widely adopted on a large scale. With the identification of key genes regulating reproduction, the elucidation of gene functions, and advances in genetic engineering techniques, sterile fish can be generated by knocking down or knocking out genes associated with reproduction. However, sterile fish produced directly through gene loss cannot pass on desirable economic traits to the next generation, making it difficult to establish stable families. Therefore, further research is needed on methods to rescue the parental sterility phenotype, such as through exogenous hormone supplementation. Conditional induced sterility and reproductive on-off strategies based on two-line hybridization represent novel approaches to reproductive containment. These techniques enable reproductive containment in fish while ensuring the stable inheritance of parental desirable economic traits. The technical approaches have been preliminarily validated in model fish species, demonstrating promising development prospects. This review summarizes advances in fish reproductive containment technologies, aiming to provide references for breeding economically valuable, ecologically friendly, and IP-protected sterile farmed fish, such as grass carp (Ctenopharyngodon idellus).
陶彬彬, 胡炜. 鱼类育性控制技术研究进展[J]. 农业生物技术学报, 2026, 34(1): 1-12.
TAO Bin-Bin, HU Wei. Research Progress on Reproductive Containment Technologies of Fish. 农业生物技术学报, 2026, 34(1): 1-12.
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