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| Study on Toxicity of Ochratoxin A by Nuclear Magnetic Resonance(NMR) Based Metabolomics |
| 1, 1,1, 1, 1, 1,韦露450103198306212562李丽婷120103198310162928 |
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Abstract Ochratoxin A(OTA) is a mycotoxin produced by several kinds of fungi growing on food source materials. OTA has been proved to be nephrotoxic, hepatotoxic, teratogenic, mutagenic and potential carcinogenic etc. to rodents and even human. In this paper, the toxicity of OTA was studied through 1H NMR(nuclear magnetic resonance) based metabolomics together with serum clinical analysis and histopathological examination. The results showed that OTA induced the damages in proximal tubular epithelial cells of rats(Rattus norvegicus). Histopathological examination illustrated that OTA induced cytoplasmic vacuolization and karyomegaly in proximal tubular epithelial cells. 1H NMR showed OTA could lead to the changes in metabolism of rats for the content of lactate, threonine, liquid, high-density lipoprotein(HDL) in plasma varied, which illustrated that OTA influenced some metabolic pathways of glycometabolism and lipid metabolism. This finding can provide valuable information to understand the metabolism of OTA from the perspective of metabolotics.
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Received: 09 August 2013
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Corresponding Authors:
韦露450103198306212562李丽婷120103198310162928
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