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Abstract The α-tocopherol transfer protein (α-TTP) is a critical regulator of vitamin E status that stimulates the movement of vitamin E in hepatocytes and facilitates the secretion of tocopherol from hepatocytes to extrahepatic tissues. Heritable mutations in α-TTP gene cause ataxia with vitamin E deficiency (AVED), which characterized by low plasma vitamin E levels and progressive neurodegeneration. This review focused on the function and molecular aspects of α-TTP activity as well as the effect of vitamin E on the expression of α-TTP. In the end, further research focuses were also discussed. Overall, this review may provide theoretical references for α-TTP and vitamin E metabolism research.
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Received: 10 September 2013
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