Abstract The α-tocopherol transfer protein (α-TTP) is a critical regulator of vitamin E status that stimulates the movement of vitamin E in hepatocytes and facilitates the secretion of tocopherol from hepatocytes to extrahepatic tissues. Heritable mutations in α-TTP gene cause ataxia with vitamin E deficiency (AVED), which characterized by low plasma vitamin E levels and progressive neurodegeneration. This review focused on the function and molecular aspects of α-TTP activity as well as the effect of vitamin E on the expression of α-TTP. In the end, further research focuses were also discussed. Overall, this review may provide theoretical references for α-TTP and vitamin E metabolism research.
NULL. Research Advance of the Influence of Vitamin E on the Expression of α-tocopherol Transfer Protein(α-TTP) and Its Corresponding Mechanisms[J]. , 2014, 22(5): 615-620.
