Abstract Platelet-derived growth factor-D (PDGF-D) is a new member of PDGF family, it can regulate many biological processes, including angiogenesis, tissue fibrosis, tumorigenesis and lipid metabolism. It was found that PDGF-D is closely related to the sheep (Ovis aries) tail fat deposition and tail type, this gene could be used as candidate gene for tail type selection. PDGF-D can specifically bind to and activate its cognate receptor PDGFRβ (platelet-derived growth factor receptor β), then regulate many cellular processes, including cell proliferation, differentiation and apoptosis. This review introduced the discovery, structure, expression, physiological function and signal transduction pathway of PDGF-D gene, proposed the research emphasis of PDGF-D gene in the future. This article provides a valuable reference for PDGF-D gene research.
[1] 赵有璋.中国养羊学[M].北京: 中国农业出版社，2013.
[2] MORADI M H, NEJATI-JAVAREMI A, MORADI-SHAHRBABAK M, et al.Genomic scan of selective sweeps in thin and fat tail sheep breeds for identifying of candidate regions associated with fat deposition[J]. [J].BMC genetics, 2012, 13(10):-
[3] WEI C H, WANG H H, LIU G, et al.Genome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds[J].[J].BMC genomics, 2015, 16(194.):-
[4]LI X R, ERIKSSON U.Novel PDGF family members: PDGF-C and PDGF-D[J].Cytokine Growth Factor Rev, 2003, 14(2):91-98
[5]LI X R, PONTEN A, AASE K, et al.PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor[J].Nat Cell Biol, 2000, 2(5):302-309
[6]BERGSTEN E, UUTELA M, LI X R, et al.PDGF-D is a specific,protease-activated ligand for the PDGF beta-receptor[J].Nat Cell Biol, 2001, 3(5):512-516
[7]ANDRAC J, GALLINI R, BETSHOLTZ C.Role of platelet-derived growth factors in physiology and medicine[J].Genes Dev, 2008, 22(10):1276-1312
[8]MA J, ZHAO Y Y, SUN L, et al.Exosomes derived from Akt-modified human umbilical cord mesenchymal stem cells improve cardiac regeneration and promote angiogenesis via activating platelet-derived growth factor D[J].Stem Cells Transl Med, 2017, 6(1):51-59
[9]PONTEN A, FOLESSTAD E B, PIETRAS K, et al.Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice[J].Circ Res, 2005, 97(10):1036-1045
[10]HUANG W, FRIDMAN Y, BONFIL R D, et al.A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growth[J].Oncogene, 2012, 31(42):4527-4535
[11]HYE K J, GYU P S, KIM W K, et al.Functional regulation of adipose-derived stem cells by PDGF-D[J].Stem cells, 2015, 33(2):542-556
[12]LAROCHELLE W J, JEFFERS M, MCDONALD W F, et al.PDGF-D,a new protease-activated growth factor[J].Nat Cell Biol, 2001, 3(5):517-521
[13]HAMADA T, UI-TEI K, IMAKI J, et al.Molecular cloning of SCDGF-B,a novel growth factor homologous to SCDGFPDGF-Cfallotein[J].Biochem Biophys Res Commun, 2001, 280(3):733-737
[14] DALLA-FAVERA R, GALLO R C, GIALLONGO A, et al.Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene[J]. [J].Science, 1982, 218(4573):686-688
[15] BETSHOLTZ C, JOHNSSON A, HELDIN C H, et al.cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines[J].[J].Nature, 1986, 320(6064):695-699
[16]UUTELA M, LAUREN J, BERGSTEN E, et al.Chromosomal location,exon structure,and vascular expression patterns of the human PDGFC and PDGFD genes[J].Circulation, 2001, 103(18):2242-2247
[17]TSAI Y J, LEE R K, LIN S P, et al.Identification of a novel platelet-derived growth factor-like gene,fallotein,in the human reproductive tract[J].Biochim Biophys Acta, 2000, 1492(1):196-202
[18]REIGSTAD L J, VARHAUG J E, LILLEHAUG J R.Structural and functional specificities of PDGF-C and PDGF-D,the novel members of the platelet-derived growth factors family[J].FEBS J, 2005, 272(22):5723-5741
[19] BORKHAM-KAMPHORST E, MEURER S K, VAN DE LEUR E, et al.PDGF-D signaling in portal myofibroblasts and hepatic stellate cells proves identical to PDGF-B via both PDGF receptor type alpha and beta[J]. [J].Cell Signal, 2015, 27(7):1305-1314
[20]CHEN J H, YUAN W Z, WU L, et al.PDGF-D promotes cell growth,aggressiveness,angiogenesis and EMT transformation of colorectal cancer by activation of Notch1Twist1 pathway[J].Oncotarget, 2017, 8(6):9961-9973
[21]OGAWA N, INOKUCHI M, TAKAGI Y, et al.Clinical significance of platelet derived growth factor-C and -D in gastric cancer[J].Oncol Lett, 2015, 10(6):3495-3501
[22]PAXIMADIS P, NAJY A J, SNYDER M, et al.The interaction between androgen receptor and PDGF-D in the radiation response of prostate carcinoma[J].Prostate, 2016, 76(6):534-542
[23] BRITO I R, SALES A D, RODRIGUES G Q, et al.Differential gene expression and immunolocalization of platelet-derived growth factors and their receptors in caprine ovaries[J].[J].Domest Anim Endocrinol, 2015, 51:46-55
[24]BRITO I R, LIMA I M, SARAIVA M V, et al.Expression levels of mRNA-encoding PDGF receptors in goat ovaries and the influence of PDGF on the in vitro development of caprine pre-antral follicles[J].Reprod Domest Anim, 2012, 47(5):695-703
[25]OKAMURA Y, MYOUMOTO A, MANABE N, et al.Protein tyrosine kinase expression in the porcine ovary[J].Mol Hum Reprod, 2001, 7(8):723-729
[26]SLEER L S, TAYLOR C C.Cell-type localization of platelet-derived growth factors and receptors in the postnatal rat ovary and follicle[J].Biol Reprod, 2007, 76(3):379-390
[27]SLEER L S, TAYLOR C C.Platelet-derived growth factors and receptors in the rat corpus luteum: localization and identification of an effect on luteogenesis[J].Biol Reprod, 2007, 76(3):391-400
[28]YOON S J, KIM K H, CHUNG H M, et al.Gene expression profiling of early follicular development in primordial,primary,and secondary follicles[J].Fertil Steril, 2006, 85(1):193-203
[29]HELDIN C H, OSTMAN A, RONNSTRAND L.Signal transduction via platelet-derived growth factor receptors[J].Biochim Biophys Acta, 1998, 1378(1):F79-113
[30]EKMAN S, BERGQVIST M, HELDIN C H, Lennartsson J.Activation of growth factor receptors in esophageal cancer--implications for therapy[J].Oncologist, 2007, 12(10):1165-1177
[31] DENNIS B.Handbook of cell signaling[M].北京：科学出版社，2011.
[32]KURASAWA K, ARAI S, OWADA T, et al.Autoantibodies against platelet-derived growth factor receptor alpha in patients with systemic lupus erythematosus[J].Mod Rheumatol, 2010, 20(5):458-465
[33]UUTELA M, WIRZENIUS M, PAAVONEN K, et al.PDGF-D induces macrophage recruitment,increased interstitial pressure,and blood vessel maturation during angiogenesis[J].Blood, 2004, 104(10):3198-3204
[34]WANG Z W, KONG D J, BANERJEE S, et al.Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling[J].Cancer Res, 2007, 67(23):11377-11385
[35]XU L, TONG R, COCHRAN D M, et al.Blocking platelet-derived growth factor-Dplatelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model[J].Cancer Res, 2005, 65(13):5711-5719
[36]LI H, FREDRIKSSON L, LI X R, et al.PDGF-D is a potent transforming and angiogenic growth factor[J].Oncogene, 2003, 22(10):1501-1510
[37]GLADH H, FOLESTAD E B, MUHL L, et al.Mice lacking platelet-derived growth factor D display a mild vascular phenotype[J].PLoS One, 2016, 11(3):e0152276-
[38]AGUILAR A.Renal fibrosis: PDGF-D in renal fibrosis[J].Nat Rev Nephrol, 2016, 12(5):257-
[39]ZHAO T Q, ZHAO W Y, CHEN Y J, et al.Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts[J].Am J Physiol Heart Circ Physiol, 2013, 304(12):H1719-1726
[40]BORKHAM-KAMPHORST E, VAN ROEYEN C R, OSTENDORF T, et al.Pro-fibrogenic potential of PDGF-D in liver fibrosis[J].J Hepatol, 2007, 46(6):1064-1074
[41]WANG Y, QIU H F, HU W X, et al.Over-expression of platelet-derived growth factor-D promotes tumor growth and invasion in endometrial cancer[J].Int J Mol Sci, 2014, 15(3):4780-4794
[42]ARETEMENKO Y, GAGNON A, AUBIN D, et al.Anti-adipogenic effect of PDGF is reversed by PKC inhibition[J].J Cell Physiol, 2005, 204(2):646-653
[43]HOLMSTROM T E, MATTSSON C L, FALTING J M, et al.Differential signalling pathways for EGF versus PDGF activation of Erk12 MAP kinase and cell proliferation in brown pre-adipocytes[J].Exp Cell Res, 2008, 314(19):3581-3592
[44]VAZIRI C, FALLER D V.Down-regulation of platelet-derived growth factor receptor expression during terminal differentiation of 3T3-L1 pre-adipocyte fibroblasts[J].J Biol Chem, 1996, 271(23):13642-13648
[45]SUMMERS S A, WHITEMAN E L, CHO H, et al.Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes[J].J Biol Chem, 1999, 274(34):23858-23867
[46]WHITEMAN E L, CHEN J J, BIRNBAUM M J.Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates[J].Endocrinology, 2003, 144(9):3811-3820
[47]BLUHER M, PATTI M E, GESTA S, et al.Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression[J].J Biol Chem, 2004, 279(30):31891-31901
[48] ZHU C Y, FAN H Y, YUAN Z H, et al.Genome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays[J]. [J].Sci Rep, 2016, 6(27822):-
[49] 袁泽湖.利用选择信号分析方法筛选与绵羊尾型相关的基因[D].北京: 中国农业科学院, 2016.
[50] 王慧华.中国地方绵羊群体结构分析及基因组选择痕迹挖掘[D].北京: 中国农业科学院, 2015.
[51]YANG J, LI W R, LV F H, et al.Whole-genome sequencing of native Sheep provides insights into rapid adaptations to extreme environments[J].Mol Biol Evol, 2016, 33(10):2576-2592
[52]ZHAO Y X, YANG J, LV F H, et al.Genomic reconstruction of the history of native sheep reveals the peopling patterns of nomads and the expansion of early pastoralism in east asia[J].Mol Biol Evol, 2017, 34(9):2380-2395
[53]ARTAVANIS-TSAKONAS S, MATSUNO K, FORTINI M E.Notch signaling[J].Science, 1995, 268(5208):225-232
[54]D'ALTRI T, GONZALEZ J, AIFANTIS I, et al.Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia[J].Cell cycle, 2011, 10(7):1031-1036
[55]AHMAD A, WANG Z W, KONG D J, et al.Platelet-derived growth factor-D contributes to aggressiveness of breast cancer cells by up-regulating Notch and NF-kappaB signaling pathways[J].Breast Cancer Res Treat, 2011, 126(1):15-25
[56]ENGELMAN J A, LUO J, CANTLEY L C.The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism[J].Nat Rev Genet, 2006, 7(8):606-619
[57]PARK Y K, JANG B C, CHOI M.Platelet-derived growth factor-D induces expression of cyclooxygenase-2 in rat mesangial cells through activation of PI3KPKB and PKCs[J].Int J Mol Med, 2013, 31(2):447-452
[58] QIN Z, FENG J F, LIU Y S, et al.PDGF-D promotes dermal fibroblast invasion in 3-dimensional extracellular matrix via Snail-mediated MT1-MMP upregulation[J]. [J].Tumour Biol, 2016, 37(1):591-599
[59]MENDOZA M C, ER E E, BLENIS J.The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation[J].Trends Biochem Sci, 2011, 36(6):320-328
[60]LOKKER N A, SULLIVAN C M, HOLLENBACH S J, et al.Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors[J].Cancer Res, 2002, 62(13):3729-3735
[61]AMMOUN S, FLAIZ C, RISTIC N, Schuldt J, Hanemann CO.Dissecting and targeting the growth factor-dependent and growth factor-independent extracellular signal-regulated kinase pathway in human schwannoma[J].Cancer Res, 2008, 68(13):5236-5245
[62]KALLURI R, WEINBERG R A.The basics of epithelial-mesenchymal transition[J].J Clin Invest, 2009, 119(6):1420-1428
[63]WU Q, HOU X, XIA J, et al.Emerging roles of PDGF-D in EMT progression during tumorigenesis[J].Cancer Treat Rev, 2013, 39(6):640-646
[64]KONG D J, WANG Z W, SARKAR S H, et al.Platelet-derived growth factor-D overexpression contributes to epithelial-mesenchymal transition of PC3 prostate cancer cells[J].Stem Cells, 2008, 26(6):1425-1435
[65]WANG Z W, ALI S, BANERJEE S, et al.Activated K-Ras and INK4aArf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype[J].J Cell Physiol, 2013, 228(3):556-562
[66]DEVARAJAN E, SONG Y H, KRISHNAPPA S, et al.Epithelial-mesenchymal transition in breast cancer lines is mediated through PDGF-D released by tissue-resident stem cells[J].Int J Cancer, 2012, 131(5):1023-1031
[67]WU Q, WANG R, YANG Q L, et al.Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway[J].Oncotarget, 2013, 4(11):1999-2009
