Contact Us Add to Favorite
 
NianQi Search Adv Search
33
农业生物技术学报  2023, Vol. 31 Issue (6): 1304-1313    DOI: 10.3969/j.issn.1674-7968.2023.06.018
Reviews and Progress Current Issue | Archive | Adv Search |
Research Progress on Mechanism of Abnormal Placental Development in Somatic Cell Cloned Animals
ZHAO Xiao-Yu, WU Shan-Shan, XU Han, LI Dan-Yi, LI Guang-Peng, SU Guang-Hua*
State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (R2BGL), Inner Mongolia University, Hohhot 010070, China
Download: PDF (957 KB)   HTML (1 KB) 
Export: BibTeX | EndNote (RIS)      
Abstract  Somatic cloning of animals has the problem of low efficiency, and its pregnancy success rate is only 1%~5%. Abnormal placenta of cloned animals is the main cause of pregnancy failure, including placental oversize, placental angiogenesis defect, trophoblast abnormality and so on. Although the mechanism of these abnormalities is unclear, the existing evidence shows that the abnormal expression of proteins and imprinted genes in the cloned placenta and the failure of key regulatory genes to establish correct apparent modification in the normal development of the placenta may be the main reasons for the morphological abnormalities and functional defects of the cloned placenta. This review describes the abnormal phenomena and possible regulatory mechanisms in cloned animals placentas, which could help us to improve the efficiency of subsequent somatic cell nuclear transfer in animals.
Key wordsSomatic cell nuclear transfer      Clone      Placenta      Imprinted genes      Epigenetic     
Received: 12 July 2022     
ZTFLH:  S8-0  
Corresponding Authors: *guanghuasu@imu.edu.cn   
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
ZHAO Xiao-Yu
WU Shan-Shan
XU Han
LI Dan-Yi
LI Guang-Peng
SU Guang-Hua
Cite this article:   
ZHAO Xiao-Yu,WU Shan-Shan,XU Han, et al. Research Progress on Mechanism of Abnormal Placental Development in Somatic Cell Cloned Animals[J]. 农业生物技术学报, 2023, 31(6): 1304-1313.
URL:  
http://journal05.magtech.org.cn/Jwk_ny/EN/10.3969/j.issn.1674-7968.2023.06.018     OR     http://journal05.magtech.org.cn/Jwk_ny/EN/Y2023/V31/I6/1304
Copyright © Editorial Board of 农业生物技术学报
Supported by:Beijing Magtech