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| Research Progress on Mechanism of Abnormal Placental Development in Somatic Cell Cloned Animals |
| ZHAO Xiao-Yu, WU Shan-Shan, XU Han, LI Dan-Yi, LI Guang-Peng, SU Guang-Hua* |
| State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock (R2BGL), Inner Mongolia University, Hohhot 010070, China |
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Abstract Somatic cloning of animals has the problem of low efficiency, and its pregnancy success rate is only 1%~5%. Abnormal placenta of cloned animals is the main cause of pregnancy failure, including placental oversize, placental angiogenesis defect, trophoblast abnormality and so on. Although the mechanism of these abnormalities is unclear, the existing evidence shows that the abnormal expression of proteins and imprinted genes in the cloned placenta and the failure of key regulatory genes to establish correct apparent modification in the normal development of the placenta may be the main reasons for the morphological abnormalities and functional defects of the cloned placenta. This review describes the abnormal phenomena and possible regulatory mechanisms in cloned animals placentas, which could help us to improve the efficiency of subsequent somatic cell nuclear transfer in animals.
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Received: 12 July 2022
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Corresponding Authors:
*guanghuasu@imu.edu.cn
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