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农业生物技术学报  2022, Vol. 30 Issue (5): 935-943    DOI: 10.3969/j.issn.1674-7968.2022.05.011
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Genetic Variation Analysis of Exon3 of MHC Gene and Its Correlation with Growth Performance in Two Goat (Capra hircus) Breeds
SUN Wang-Bin1,*, WANG Wei-Ping1, HUANG Yan2, SONG Xiao-Yue1, ZHANG Di1, SHANG Jia-Le1, ZHANGSUN Wei-Guang1, LI Zeng-Hui1
1 Shaanxi Province Engineering & Technology Research Center of Shanbei Cashmere Goats, Yulin University, Yulin 719000, China;
2 Yuyang District Animal Disease Prevention and Control Center, Yulin 719000, China
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Abstract  Shanbei white cashmere goat (Capra hircus) and Ziwuling black goat are the main goats in the northern of Shaanxi, but their growth performance needs to be improved. Especially, the population size of the latter decreased sharply, so it is urgent to determine the genetic variation of its population. Genetic variation of major histocompatibility complex (MHC) genes can be used to evaluate population genetic diversity, and MHC genes are also associated with body size traits of domestic animals. The aim of this study was to investigate the polymorphism of major histocompatibility complex (MHC) gene exon3 in Shanbei white cashmere goat and Ziwuling black goat, and to evaluate the population development trend of Ziwuling black goat, and to explore the correlation between MHC gene and growth performance or cashmere traits in Shanbei white cashmere goats. In this study, the genetic variation of exon3 of MHC gene of 600 Shanbei white cashmere goats and 30 Ziwuling black goats was analyzed by using high-throughput sequencing method, and the correlation between MHC gene and growth performance was studied. Exon3 sequences of 2 MHC genes were obtained, including 4 DQA1 alleles and 22 DQB2 alleles. The heterozygosity and polymorphism of Ziwuling black goat were low, and the population development trend was not optimistic, so effective protection measures should be taken. Moreover, Shanbei white cashmere goats had higher polymorphism, the BB genotype of DQA1 gene was significantly higher than the other 2 genotypes in terms of height at hip cross and wool length (P=0.035, P=0.021), and the AA genotype had the smallest cashmere fineness (P=0.003). These alleles could be used as an effective molecular marker for growth performance improvement and ultrafine cashmere goat breeding, respectively. The results of this study are helpful to promote molecular markerassisted selection breeding of Shanbei white cashmere goat, and the protection, development and utilization of Ziwuling black goat germplasm resources.
Key wordsShanbei white cashmere goats      Ziwuling black goat      DQA1 gene      DQB2 gene      Genetic variation      Genetic resource conservation     
Received: 07 June 2021     
ZTFLH:  S834.8  
Corresponding Authors: *ylsunwb@sina.com   
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Articles by authors
SUN Wang-Bin
WANG Wei-Ping
HUANG Yan
SONG Xiao-Yue
ZHANG Di
SHANG Jia-Le
ZHANGSUN Wei-Guang
LI Zeng-Hui
Cite this article:   
SUN Wang-Bin,WANG Wei-Ping,HUANG Yan, et al. Genetic Variation Analysis of Exon3 of MHC Gene and Its Correlation with Growth Performance in Two Goat (Capra hircus) Breeds[J]. 农业生物技术学报, 2022, 30(5): 935-943.
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http://journal05.magtech.org.cn/Jwk_ny/EN/10.3969/j.issn.1674-7968.2022.05.011     OR     http://journal05.magtech.org.cn/Jwk_ny/EN/Y2022/V30/I5/935
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