Progress on Lin28 in the Regulation of Mammal Reproduction
CAO Gui-Ling1,2,*, JIANG Yun-Liang2, CHU Ming-Xing3,*
1 College of Agriculture, Liaocheng University, Liaocheng 252059, China; 2 College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Taian 271018, China; 3 Key Laboratory of Animal (Poultry) Genetics and Breeding and Reproduction of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Abstract Lin28a and Lin28b, as RNA-binding proteins, bind to the terminal loop of pri- and pre-let-7 miRNA and repress their processing; also bind to target mRNA to modulate their translation, and mediate several physiological processes, such as cell pluripotency maintenance, tumorigenesis and glucose metabolism. Some new researches discovered that Lin28a and Lin28b may participate in human and animal reproduction, and the action mechanisms remain ill defined. The present paper reviews the research progress on the role of Lin28a and Lin28b genes in onset of mammalian puberty, primordial germ cell (PGCs) formation and gametogenesis, and provide some reference for further studies on their roles in animal reproduction.
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