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| Research Measures for Copy Number Variation and its Research Progress in Livestock and Poultry |
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Abstract Copy number variation (CNV) is an important source of genetic variation complementary to single nucleotide polymorphism (SNP). It has been shown not only relating with disease susceptibility and developmental abnormality, and also with appearance characteristics and economically important traits. Combined using the SNP and CNV will provide new research ideas for dissecting the molecular mechanism and genetic basement of complex traits of livestock and poultry. Additionally, CNV would have broad application in marker assistant selection in breeding of livestock and poultry. Genome-wide CNV discovery approaches include array comparative genome hybridization (CGH), high dense SNP chips and newly developed genome re-sequence based on high-throughput sequencing technologies. Since 2008, using hybridization- based chip and sequencing-based technologies, a series of studies have been performed to construct CNV maps in every livestock and poultry. In the present article, we summarized the detection measures to identify genome-wide CNV, methods for genotyping the detected CNV, and the considerable advances of CNV in livestock and poultry. It will provide useful information for researchers engaged in the field.
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Received: 12 October 2012
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ZHAO Zhong-Hai, ZHOU Di, LI Hui, YI Heng-Jie, LONG Qing-Meng, SHI Xin-Cai, BU Xiao-Yan, Chen Lin, YANG Hua-Ting, LI Xing-Cai. Genetic Diversity and Origin of Guizhou Pig (Sus scrofa domesticus) Breeds Analyzed by mtDNA D-loop Region[J]. 农业生物技术学报, 2019, 27(7): 1206-1214. |
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