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| Distribution and Expression of Interleukin-2 and -10 in Thymus of Spontaneous Aborted Foetus of Rhesus Macaques (Macacca mulatta) |
| 1, 1, 1,Chen Zheng-Li 1, 1 |
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Abstract Mammalian thymus is the central immune organ. In order to investigate the immune response of the central immune organ in fetal rhesus macaques when aborted, spontaneous aborted fetuses were used as experimental material and the distribution and expression of their interleukin-2 and -10(IL-2+ and IL-10+) cells were determined by HE staining and immunohistochemical staining in different gestational age of fetal rhesus macaques. Results: Interlobular dividing lines of the fetal thymus in macaques in each gestational age group were clear. The number of lobules and lymphocytes in cortical medulla were increased by month-to-month. In two-month embryo age, medulla was formatted and diffuse thymus vorkommen was appeared. , In three-month embryo age, typical thymus vorkommen was observed in medulla and the thymus structure was organized. Thymus IL-2 and IL-10 expression in the 1-month-old was negative. After that, the optical density and the area ratio of positive cells were increased with the development of age. Positive cells were distributed in the cortical edge, the junction of cortex and medulla, the central area of the medulla, and the thymus body without degradation and blood vessels around the thymus. Furthermore, the expression of IL-2 was high, whereas the expression of IL-10 was low. The results suggest that two cytokines, especially IL-2, were mainly expressed in thymocytes' growth area. In addition, secretion levels of IL-2 and IL-10 can be as a predictor of premature of pregnant women.
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Received: 25 May 2011
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Corresponding Authors:
Chen Zheng-Li
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