甘氨酸-N-甲基转移酶对肝脏代谢及相关疾病的调控机制

doi:10.3969/j.issn.1674-7968.2022.11.015

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Abstract The liver, a vital functional organ of the human body, can metabolize various substances and transport them to other parts of the body for utilization and excretion. It also has a plenty of physiological functions such as detoxification and the synthesis, metabolism, digestion and storage of various substances. Among them, fat and energy metabolism are particularly important. If this process becomes abnormal, including excessive fat synthesis, reduced metabolism, and decreased transport capacity, will cause the risk of a variety of diseases such as non-alcoholic fatty liver disease, liver fibrosis and cirrhosis, cholestasis, and even liver cell carcinoma rising rapidly. Liver is also closely related to the induction of other metabolic diseases. Recent studies have declared that glycine-N-methyltransferase (GNMT) in the liver acts as a key enzyme that regulates the conversion of S-adenosylmethionine (SAM) to S-adenosyl homocysteine (SAH), which can change the in-body level of SAM and then regulates the body's methylation status. GNMT can also alter the expression of fat metabolism and transport related genes, as well as the activity of oxidative respiratory complexⅡ to regulate fat content and reduce the occurrence and further development of diseases. This review describes the regulatory effects of GNMT on lipid metabolism, glucose metabolism, and oxidative stress in the liver. The therapeutic effects of GNMT in a variety of liver diseases are also discussed. This article can lay a solid theoretical foundation for future treatment methods and targets aim to GNMT.

Key words： Glycine-N-methyltransferase (GNMT) Lipid metabolism Methyl cycle Liver disease

Received: 26 November 2021

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Corresponding Authors: * caoyangchun@126.com

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	DU Xue-Er
	WANG Jian-Guo
	YAO Jun-Hu
	CAO Yang-Chun

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DU Xue-Er,WANG Jian-Guo,YAO Jun-Hu, et al. The Regulation Mechanism of Glycine-N-methyltransferase on Liver Metabolism and Related Diseases[J]. 农业生物技术学报, 2022, 30(11): 2224-2235.

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http://journal05.magtech.org.cn/Jwk_ny/EN/10.3969/j.issn.1674-7968.2022.11.015 OR http://journal05.magtech.org.cn/Jwk_ny/EN/Y2022/V30/I11/2224

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