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| Research Advances on Attenuated Listeria monocytogenes as a Vaccine Platform for Cancer Immunotherapy |
| CHEN Lu1,*, WANG Feng-Ting1,*, SUN Jing1,2,3, CHEN Zhong-Wei1,2,3, WEI Fang-Fang1,2,3, SONG Hou-Hui1,2,3,**, CHENG Chang-Yong1,2,3,** |
1 College of Animal Science and Technology·College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China;
2 Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Hangzhou 311300, China;
3 Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, Hangzhou 311300, China |
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Abstract Listeria monocytogenes is a Gram-positive facultative intracellular bacterial pathogen that can infect humans and animals, causing listeriosis in neonates, pregnant women, elderly persons, and individuals whose immune system is compromised. Live L. monocytogenes is adept at generating strong antigen-specific T-cell responses due to its unique features during host infection, making it an attractive vector for cancer immunotherapy. Increasing studies have shown that the attenuated Listeria is becoming an efficient tool for cancer immunotherapy. Several Listeria-based tumor vaccines undergo being developed, such as the cervical cancer and canine osteosarcoma. Clinical trials have exhibited impressive therapeutic efficacy in these cancer models. This review will summarize the recent studies and progress about Listeria-based cancer immunotherapy, which will help readers understand the current technology and development of tumor immunotherapy vaccines. This review could provide a reference for developing new strategies and technologies for tumor prevention and treatment.
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Received: 20 November 2020
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Corresponding Authors:
** lamge@zafu.edu.cn; songhh@zafu.edu.cn
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| About author:: * These authors contributed equally to this work |
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