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| Research Progress of GDF8 Function in Reproductive System |
| REN Xue-Hua1,2, LEI An-Min1,2,* |
1 College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China;
2 Shaanxi Stem Cell Engineering and Technology Research Center, Yangling 712100, China |
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Abstract The growth differentiation factor 8 (GDF8) gene is a member of the transforming growth factor-β(TGF-β) superfamily. In addition to acting as a negative regulator of muscle growth, it also functions in various biological processes such as lipid metabolism and sugar metabolism. Recently, the functional role of GDF8 in reproductive organs has received increased interest. Studies have found that GDF8 and its receptors are expressed in uterus, ovaries, fallopian tubes, embryos and other tissues and play important physiological roles, including participating in follicular development and ovulation, regulating the synthesis of follicular steroid hormones, affecting the formation of extracellular matrix and the proliferation, differentiation and diffusion of granular cells, and is closely related to the outcome of pregnancy. This article will review the research progress of GDF8 in the reproductive system based on domestic and foreign literature, in order to provide a reference for subsequent research.
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Received: 03 August 2020
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| Fund:国家转基因生物新品种培育重大专项（No.2016ZX08006003) |
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Corresponding Authors:
*anminleiryan@nwsuaf.edu.cn
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