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Research Progress of Keratin-related Proteins Related to Hair Fiber Traits |
HE Dong-Qian1, TAO Jin-Zhong1,*, CHEN Li-Yao1, WANG Jun-Kui1 |
School of Agriculture, Ningxia University, Yinchuan 750021, China |
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Abstract Wool fiber is one of the important economic products of sheep. The development of the wool market has stimulated people's demand for different characteristics of wool. Peratin-associated proteins (KAPs)genes--KRTAPs and keratin-associated proteins (KIFs) genes and their respective variant genes are candidate genes for identifying the genetic basis of wool fiber differences. Using the homologous genes of human or goat and other mammalian keratins, we can identify the sheep genome and explore new potential functional KRTAPs or KIFs genes. In this review, the morphological structure of hair follicles is introduced, and the development of keratin-related protein genes is reviewed. The expression and location of KAP protein in hair follicles are also described. Finally, the effect of KRTAPs gene polymorphism on wool traits is summarized. This review provides a theoretical basis for the molecular breeding of sheep hair follicle growth and development and hair fiber traits.
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Received: 16 September 2020
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Corresponding Authors:
* tao_jz@nxu.edu.cn
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