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2025年7月30日 星期三
  研究论文 本期目录 | 过刊浏览 | 高级检索 |
突变型抑癌基因p53在蛋鸡J亚群禽白血病中的表达
徐镔蕊1 董卫星2 何召庆1 余春明1 李 宁1 冯小宇1 L.F.Lee3 Maoxiang Li3
(1. 中国农业大学动物医学院, 北京 100094; 2. 安徽省农业委员会畜牧局,合肥 230001;
3. Avian Disease and Oncology Laboratory,United States Department of Agriculture,East Lansing,MI 48823, USA)
Expression of Mutant Tumor Suppressor Gene p53 in Egg-type Chicken
 Infected with Avian Leukosis Viruse Subgroup J
Xu Binrui1 Dong Weixing2 He Zhaoqing1 Yu Chunming1 Li Ning1
Feng Xiaoyu 1 L.F. Lee3 Maoxiang Li3
(1. College of Animal Medicine, China Agricultural University , Beijing 100094, China; 2. Animal Husbandry Bureau, Anhui Agricultural Committee, Hefei 230001 ,China; 3. Avian Disease and Oncology Laboratory, United States Department of Agriculture,East Lansing, MI 48823, USA)
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摘要 摘要: 蛋鸡J亚群禽白血病是病毒引起的肿瘤性传染病。为了探讨J亚群禽白血病病毒的致癌分子机理, 观察蛋用型鸡发生J亚群禽白血病时p53抑癌基因在各脏器中的表达, 应用链霉亲和素-生物素-过氧化物酶复合物免疫组化(SABC)法,研究了蛋用型鸡J亚群禽白血病自然病例的肝脏、肾脏、腺胃、肿瘤、输卵管、心脏、胰脏、骨髓、脾脏、肺脏、十二指肠、胸腺和法氏囊。结果表明:突变型p53在肝脏、肾脏、腺胃、肿瘤、输卵管中表达量最高,心脏、胰脏、骨髓、脾脏、肺脏、十二指肠、胸腺及法氏囊均可检出中等量的表达。这一结果提示突变型抑癌基因p53的表达参与蛋鸡J亚群禽白血病发生、发展过程。
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徐镔蕊
董卫星
何召庆
余春明
李宁
冯小宇
L.F.Lee
MaoxiangLi
关键词 关键词: P53抑癌基因 J亚群禽白血病 蛋用型鸡    
AbstractAbstract:Avian leukosis in egg-type chickens is infectious neoplastic disease caused by avian leukosis viruse subgroup J( ALV-J). Expression of mutant tumor suppressor gene p53 in egg-type chicken with avian leukosis subgroup J was detected to study cancericidally molecular mechanism of ALV-J. Using immunohistochemistry method of strep avidin-biotin complex (SABC),  many organs of illed egg-type chickens, involved liver, kidney, ventriculus glandularis, tumor, heart, pancreas, bone marrow, spleen, oviduct, lung, duodenum, thymus and bursa of fabricius were studied. And large numbers of mutant p53 protein were expressed in liver, kidney, ventriculus glandularis, tumor, oviduct. Moderate expression were detected in heart, pancreas, bone marrow, spleen, lung, duodenum, thymus and bursa of fabricius. The result suggested that expression of tumor suppressor gene p53 was concerned with occurrence and development of avian leukosis subgroup J.
Key wordsKey words: p53 tumor suppressor gene    avian leukosis subgroup J    egg-type chicken
收稿日期: 1900-01-01     
引用本文:   
徐镔蕊1 董卫星2 何召庆1 余春明1 李 宁1 冯小宇1 L.F.Lee3 Maoxiang Li3. 突变型抑癌基因p53在蛋鸡J亚群禽白血病中的表达[J]. , 2003, 11(3): 276-279.
Xu Binrui1 Dong Weixing2 He Zhaoqing1 Yu Chunming1 Li Ning1
Feng Xiaoyu 1 L.F. Lee3 Maoxiang Li3
. Expression of Mutant Tumor Suppressor Gene p53 in Egg-type Chicken
 Infected with Avian Leukosis Viruse Subgroup J
. , 2003, 11(3): 276-279.
链接本文:  
http://journal05.magtech.org.cn/Jwk_ny/CN/      或     http://journal05.magtech.org.cn/Jwk_ny/CN/Y2003/V11/I3/276
 
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