Abstract：Ochratoxin A(OTA) is a mycotoxin produced by several kinds of fungi growing on food source materials. OTA has been proved to be nephrotoxic, hepatotoxic, teratogenic, mutagenic and potential carcinogenic etc. to rodents and even human. In this paper, the toxicity of OTA was studied through 1H NMR(nuclear magnetic resonance) based metabolomics together with serum clinical analysis and histopathological examination. The results showed that OTA induced the damages in proximal tubular epithelial cells of rats(Rattus norvegicus). Histopathological examination illustrated that OTA induced cytoplasmic vacuolization and karyomegaly in proximal tubular epithelial cells. 1H NMR showed OTA could lead to the changes in metabolism of rats for the content of lactate, threonine, liquid, high-density lipoprotein(HDL) in plasma varied, which illustrated that OTA influenced some metabolic pathways of glycometabolism and lipid metabolism. This finding can provide valuable information to understand the metabolism of OTA from the perspective of metabolotics.
夏凯1,贺晓云2,3,郝俊冉1,黄昆仑1,梁志宏1,许文涛4. 基于核磁共振扫描(NMR)的赭曲霉毒素A毒性血浆代谢组学研究[J]. , 2013, 21(12): 1426-1433.
1, 1,1, 1, 1, 1,韦露450103198306212562李丽婷120103198310162928. Study on Toxicity of Ochratoxin A by Nuclear Magnetic Resonance(NMR) Based Metabolomics. , 2013, 21(12): 1426-1433.
